Studies of Immune Functions with Chronic Hepatitis of Patients
نویسندگان
چکیده
NONOMURA, A., TANINO, M., KURUMAYA, H., OHTA, G., KATO, Y. and KoBAYASHI, K. Studies of Immune Functions of Patients with Chronic Hepatitis. Tohoku J. exp. Med., 1982, 137 (2), 163-177 Peripheral T cells from patients with chronic active hepatitis (CAH) showed a significantly decreased suppressor effect (or increased helperr effect) on allogeneic B cell differentiation into Ig-producing cells (Ig-PC) (p<0.05). After irradiation of T cells to eliminate suppressor influences, mean spontaneous helper activity of CAR was not different from that of healthy subjects, indicating that spontaneous helper activity of CAR was normal. Concanavalin A (Con A)-induced suppressor cell activity was significantly decreased in CAR (p <0.01, 9 defective cases out of 18 patients). Minor defect of Con A-induced suppressor activity was also found in some patients with chronic persistent hepatitis (CPH) (2 defective cases out of 14 patients). Autologous mixed lymphocyte reaction (AMLR) was significantly decreased in patients with CAR (p<0.005). Spontaneous suppressor or Con Ainduced suppressor activity was not different statistically between HBsAgpositive and HBsAg-negative cases. Finally, we demonstrated a presence of a serum factor(s) that can decrease Con A-induced suppressor cell function of healthy subjects in 7 of 21 patients with CAR and 2 of 14 CPH. Our results suggest that defective suppressor cell function likely attributable to serum factor(s) may reflect altered immune responses of CAH. suppressor cell; helper cell; autologous MLR; CAH
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